Hyperthermia is a rapidly developing treatment method in cancer- and tumor-therapy. HOT-OncoTherm is dealing with a new and highly effective hyperthermia method: OncoThermia.
Conventional hyperthermia applies heat to achieve curative influence. The consequence of the regional overheating is the higher metabolism in the tumor-region. The expected effect was mainly to change the pH-environment of the malignant tissue by the elevated temperature based on the higher rate of metabolism, accompanied with the lack of the increased blood perfusion. The consequential oxygen deprivation and nutrient impoverishment will generate massive acidosis because of the anaerobic energy production. This mechanism denatures the enzymes and proteins in the tumor tissue. Anyway, the tumor cells are characterized by reduced thermo-regulation capability, allowing a significant instability by their overheating to unsettle the tumor from the state of equilibrium growth.
Starting from the alternative medicine methods used in ancient cultures, various procedures have been applied to deliver heat into the malignant area, but the stable and calculable effect could not be completed.
The delivered heat in the classical hyperthermia brings up some problems as well. The treatment temperature has been considered as the main technical parameter. Unfortunately, the heat-shock protein (HSP) synthesis may considerably suppress the cancer treatment’s efficiency, adapting cells to survive the shock.
This troubling area is exactly the target place that OncoThermia method is dealing with. OncoThermia is known as hyperthermia updated technique, which uses specifically modified the application of an electric field to avoid high production of HSP in malignant cells and overcomes typical drawbacks of conventional hyperthermia treatment. OncoThermia devices and equipment achieve selectiveness by thermally stimulating only extracellular region and consequentially provoking higher rates of metabolism without production of HSP. The patient is integrated into the thermo-electric circuit and the achieved temperature of tissues is precisely monitored by multiple microprocessors detecting reflected and absorbed energy.